High Performance TLC-MALDI

Poster

Expression Proteomics

PMM: 386

MALDI-TOF

2009

Martin Schürenberg1, Beate Fuchs2, Annabell Bischoff2, Rosemarie Süß2, Detlev Suckau2, Jürgen Schiller2 and Gerda Morlock3

Poster IMSC 2009

Abstract

HPTLC-MALDI is a largely automated, software-supported new method:

• Chromatographic resolution of HPTLC is maintained throughout the MALDI analysis Fig. 1
• Reproducibility of HPTLC-MALDI is in the 10 % range Fig. 2
• Sensitivity of HPTLC-MALDI for lipids is in the 100 ng range Fig. 3
• Structural analysis can directly follow up using HPTLC-MALDI-MS/MS Fig. 4
• Suitable for lipid analysis for clinical, nutritional, pharmaceutical and cosmetic analysis

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