MALDI tissue imaging: mass spectrometric localization of biomarkers in tissue slices
| Type: | Application |
Application Note |
Expression Proteomics, Clinical Proteomics |
| Number: | Technology |
nmeth05-2007 |
MALDI-TOF |
| Year | Products |
2007 |
ImagePrep, autoflex III smartbeam, MALDI Molecular Imager, ClassImaging, flexImaging, ClinProTools |
| Author | |
Martin Schuerenberg, Christine Luebbert, Sören-Oliver Deininger, Ralf Ketterlinus & Detlev Suckau |
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| Reference | |
Nature Methods - 4, (2007) |
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Abstract |
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New mass-spectrometric proteomics technologies have been developed with the potential to transition from pure research applications into the diagnostic laboratory. Of these, one very promising technique has already gained much interest in the research community: matrix-assisted laser desorption/ionization (MALDI) molecular imaging. For easy and successful application of MALDI imaging in the laboratory, Bruker Daltonics offers an innovative product line: a stand-alone automated sample preparation device, ImagePrep™; mass spectrometers with vital smartbeam™ laser technology: namely, the autoflex III™ and ultraflex III™ MALDI–tandem time-of-flight (MALDI-TOF/TOF) instruments; and sophisticated software tools for fast data evaluation and biomarker visualization, flexImaging™. |
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