Language
CMC - An Integrated Spectroscopy Solution
| Type: | Application |
Application Note |
|
| Number: | Technology |
01/09 T13098 US |
OTOF |
| Year | Products |
2009 |
AVANCE™ III, micrOTOF-Q II |
| Author | |
Ulrich Braumann at Bruker BioSpin and Herbert Thiele at Bruker Daltonik |
|
| Reference | |
Bruker BioSpin 01/09 T00000 US |
|
Abstract |
|
Ulrich Braumann at Bruker BioSpin and Herbert Thiele at Bruker Daltonik analyze structure verification of small molecules using integrated MS spectrometry and NMR spectroscopy.
In service laboratories in the pharma industry today, chemists synthesize huge numbers of different compounds on the basis of parallel synthesis and combinatorial chemistry, which must be verified. One main aspect is the confirmation of chemical identity and information about molecular formulae to identify possibly present impurities. Most often, a screening approach is applied in order to obtain a rough estimation on the purity, concentration and identity of the synthesized products. This flags up samples below a certain purity or those with too many impurities or samples that are not what they are considered to be. It is often impossible to use all samples at the same time; therefore most of the samples are stored in libraries for later use. Undertaking quality control on a regular basis is mandatory in order to |
|
Related Products |
|
Download |
|
