Language
MALDI Tissue Imaging and Top-Down Sequencing for Biomarker Discovery and Identification
| Type: | Application |
Poster |
Expression Proteomics |
| Number: | Technology |
HUPO 2011 #P1455 |
MALDI-TOF |
| Year | Products |
2011 |
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| Author | |
S. Rauser1; C. Marquardt1; B. Balluff1,2; C. Albers3; E. Belau3; R. Hartmer3; D. Suckau3; K. Specht4; M.P. Ebert2; M. Schmitt5; M. Aubele1; H. Höfler1; U. Anders3; A. Walch1 |
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| Reference | |
HUPO 2011 #P1455 |
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Abstract |
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A peptide marker panel for HER2+ breast cancer was discovered and validated by MALDI tissue imaging. For the subsequent top-down protein identification. ETD/PTR on an ion trap was applied. CRIP1, a new cytosolic protein marker for HER2+ breast cancer tissue was identified. The study proves the benefits of the workflow for proteomics. |
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