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Small Molecule Drug Imaging of Mouse Tissue by MALDI-TOF/TOF Mass Spectrometry and FTMS
| Type: | Application |
Application Note |
Gen. Pharma & Chemistry |
| Number: | Technology |
MT-93/FTMS-38 |
MALDI-TOF, FTMS |
| Year | Products |
2008 |
ImagePrep, autoflex III TOF/TOF, ultraflex III TOF/TOF, apex-ultra FTMS |
| Author | |
Stefen Laukien, The Rivers School (Weston, MA) Co-Authors: Emily Creedon (The Rivers School), Jane-Marie Kowalski, Paul Kowalski, Katherine Kellersberger (Bruker Daltonics), Professor Nathalie Agar (Harvard Medical School). Science Internship at Bruker Daltonics, Summer 2008 |
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| Reference | |
Bruker Daltonics Application Note MT-93/FTMS-38 |
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Abstract |
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Matrix Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry (MS) with a computer-controlled xy-stage in the ionization source can be used to detect the presence, approximate amount and location of small molecules, lipids, peptides and proteins in tissue samples through in vitro molecular imaging, often referred to as MALDI imaging. Both MALDI - Time-of-flight/Time-of-flight (MALDI-TOF/TOF MS) and MALDI - Fourier Transform Mass Spectrometry (FTMS) were used to detect and image the location of Erlotinib in various mouse tissues. The molecular imaging experiments not only indicated where in the mouse’s body the drug accumulated, but it also gave insight regarding the different MALDI imaging technologies’ respective capabilities for small molecule drug tissue imaging. |
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