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Time-course Reproducibility of Clinical Samples using Retentate Chromatography MALDI-TOF Mass Spectrometry
| Type: | Application |
Poster |
Expression Proteomics |
| Number: | Technology |
ASMS 2010 |
MALDI-TOF |
| Year | Products |
2010 |
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| Author | |
Sabine Jourdain(1), Amanda Bulman(2), Waltraud Passlack(3), Sonja Hartwig(3), Akos Czibere(4), Stefan Lehr(3), Fiona Plows(2) and Enrique Dalmasso(2); 1Bio-Rad Laboratories, Division Bio-Recherche, Marnes la Coquette, France; 2Bio-Rad Laboratories, Inc., Hercules, CA, USA; 3Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany; 4Harvard Stem Cell Institute, Boston, MA, USA |
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| Reference | |
ASMS 2010 |
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Abstract |
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IntroductionSuccess for biomarker discovery projects in clinical proteomics relies primarily on analytical and long-term reproducibility. Sample collection, sample preparation and performance of analytical instruments can all contribute to output signal variability. In order to ensure that discovered differences of expression are physiological and not introduced by experimental variability, any biomarker discovery study should include a means to monitor reproducibility. |
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