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DirectProbe DIP: Instant answers from solid samples with APCI or APPI
The DirectProbe (DIP) add-on for the Bruker APCI II and APPI II ion source allows direct analysis of liquid and solid samples without tedious sample preparation. In routine organic synthesis analyses, it simplifies identification and characterization of chemical reaction products without compromising sensitivity.
- The DirectProbe enables analysis of a wide range of substances – e.g. drug materials, steroids, food and raw plant material – down to the sub-pmol concentration range.
- Extremely sensitive down to the sub-ng range of pure substance – amount not visible at all !
- Minimum sample preparation
- Direct analysis of liquid & solid samples
- Short analysis time
- No memory due to single-use glass tubes
- This example shows the unambiguous identification of a synthetic compound using the autoMSn capability of an amaZon SL ion trap system. During the vaporization of solid (refer to TIC insert) data-dependent MS2 and MS3 spectra are taken. Note that after a simple neutral loss in MS2, MS3 provides rich structural information. Samples were kindly provided by SiChem GmbH, Bremen, Germany.
Fields of applications are
- General Chemistry → Synthesis control
- Manual quality control of solids (Pharma, oil, explosives)
- Customs → Drugs of abuse, explosives
- Homeland security
- Environmental
- Thermal degradation processes (plastic production)
- Classical routine analysis (e.g. confirmation of sum formula)
DIP is available as an option for APCI II and APPI II on all active Bruker electrospray mass spectrometers.
Related products
amaZon seriesESI-TOF-seriesmaXissolariX seriesAPCI IIAPPI II
Further reading
TN38: Fast and reliable Reaction Yield and Compound Purity Assessment in Synthesis Quality Control
