Bruker solutions for Bottom-up Strategies

PRIME : adressing the most complex bottom-up samples

Get access to the multidimensional power

Each prime component offers state-of the art bottom-up ID performances on top of other capacities enhancing their proteomics capabilities. Combining ESI and MALDI data in PRIME allows to access even greater sequence coverage and number of identified peptides - completing the dimensions to get more certainty, more knowledge.

maXis impact: The ultimate LC-MS/MS bottom-up Proteomics instrument,  enabling quick and sensitive ID’s ( Top 30 method with up to > 480 peptides /min @ 20hz MS/MS), > 2600 ID’s from a 120 min gradient) AND accurate quantitation (Unique inter and Intra spectra dynamic range providing 4 orders of magnitude linearity,  accessible mass range in MS/MS to combine identification and accurate isobaric quantitation)

amaZon speed: The proteomic workhorse, able to provide Id’s from complex mixtures @ > 8 Hz MS/MS , able to MS 12th to decipher glycopeptide structures or intelligent ETD/CID combining fragmentation strategies to locate and characterize labile PTMs.

ultrafleXtreme and autoflex speed: capable of Ultra-fast LC-MALDI for Bottom-up protein ID’s while sorting and characterizing glycopeptides in the same run. Providing an extra 20% ID’s  bringing unique imaging and Top-down capabilities in the lab.