Accelerated nanoLC-MALDI-TOF/TOF Analysis of Complex Proteomics Samples Performed at a New Level of Resolution and Mass Accuracy

Application Note

Expression Proteomics

MT-100

MALDI-TOF

2009

ultrafleXtreme EASY-nanoLC PROTEINEER fc II MTP AnchorChip 800-384 ProteinScape

Arndt Asperger, Stephanie Hahner, Anja Resemann, Marcus Macht; Bruker Daltonics, Bremen, Germany

Bruker Daltonics Application Note MT-100

Abstract

Sample complexity continues to be one of the most challenging aspects for researchers in the field of expression proteomics. Various separation techniques are commonly applied at both the protein and peptide level to reduce the complexity of a proteome to be analyzed. However, despite these efforts, the number of compounds present in proteomics samples may still be considerable.

Mass spectrometers are invaluable tools for the analysis of such complex proteomics samples. Their effectiveness is directly related to the ability to achieve several factors simultaneously, these include:

• fast acquisition speed
• high resolution and mass accuracy
• high sensitivity and dynamic range
• long term robustness and reliability 

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