Towards 100% sequence coverage in protein QC using the ProteinScape database software
| Type: | Application |
Poster |
Expression Proteomics |
| Number: | Technology |
DGMS 2010 |
MALDI-TOF, UHR-TOF, FTMS |
| Year | Products |
2010 |
EASY-nano LC, ultrafleXtreme, PROTEINEER fc II, maXis, solariX |
| Author | |
A. Asperger, U. Schweiger-Hufnagel, P. Hufnagel, R. Hebeler, M. Witt, P.-O. Schmit, M. Macht; Bruker Daltonik GmbH, Fahrenheitstrasse 4, 28359 Bremen, Germany |
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| Reference | |
DGMS |
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Abstract |
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Quality control of biotherapeutic proteins requires access to the full protein sequence to account for every single aminoacid and its modification status. This is typically not achieved in a single LC-MS/MS analysis, but requires combined analytical strategies. However, this complicates the downstream data analysis due to distribution of relevant information in multiple datasets. A new bioinformatics platform, ProteinScape, is described here, which facilitates in-depth protein characterization tasks at an unparalleled level of efficiency. |
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