Using Gas Chromatography – Tandem Mass Spectrometry to Improve the Reliability and Accuracy of Organic Acid Analyses in Urine
| Type: | Application |
Application Note |
Metabolomics Studies |
| Number: | Technology |
CA-271518 |
GC/MS |
| Year | Products |
2010 |
Bruker 320-MS CTC Combi-PAL Liquid Autosampler |
| Author | |
Kurt Thaxton, Patrick M. Jeanville, Ph.D. and Robert Kubas, Bruker Daltonics |
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| Reference | |
Bruker Daltonics Application Note CA-271518 |
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Abstract |
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Organic acids are water-soluble compounds containing one or more carboxyl groups, as well as other functional groups (-keto, -hydroxy). They occur as physiologic intermediates in a variety of metabolic pathways. The organic acidurias are a group of disorders in which one or more of these pathways are blocked, resulting in a deficiency of normal products and an abnormal accumulation of intermediate metabolites (organic acids) in the body. These excess metabolites are excreted in the urine and can be analyzed by capillary gas chromatography-mass spectrometry (GC-MS). Herein we describe a tandem GC/MS approach for analysis of fifteen organic acids in newborn urine.
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